Commentary

Pathways for Vaccine Damage

Pathways for Vaccine Damage

To whom it may concern,

The WHO has recently published a statement listing the ten most imminent health challenges for humanity in 2019 [1].  The list includes a crusade against so-called ‘vaccine sceptics’, i.e. people who challenge the safety and effectiveness of national immunisation programs.
Considering that there is no independent control of these two important parameters in today’s vaccine programs and the industry alone is responsible for delivering data on their products, there is significant cause for concern when comparing these data with investigation by independent sources.  The press is now claiming that “vaccine critics are one of the greatest health risks for humanity.”  Science would tend however to suggest that on the contrary;it is a lack of vaccine safety, which is one of humanity’s greatest health risks.

The European Forum for Vaccine Vigilance (EFVV) is an association demanding freedom of informed vaccine consent and application of the precautionary principle with respect to vaccines in Europe and beyond.   Many countries have vaccine injury payment schemes and sums paid out for vaccine adverse effects are significant: more than $4 billion total in the USA and over  £74 million over 39 years in the UK.  In the UK, claims will only be considered in persons over two years of age [2]  xx , precluding claims relating to most of the vaccine schedule.  In addition, the adverse reactions acknowledged by vaccine injury compensation schemes only deal with side effects in close proximity to the vaccine administered whereas it can take time for an autoimmune condition to manifest and often victims have to prove over 50% disability linked with the vaccine.  According to a US government-funded Harvard Medical School study, ‘fewer than 1% of vaccine adverse events are reported’ [3], so these staggering figures will represent only a very tiny fraction of the real number. The European Union’s recent resolution on vaccine hesitancy also states clearly that transparency and safety monitoring in this field are insufficient.  Vaccine safety is therefore a topic of significant concern, requiring further investigation before any vaccine is mandated anywhere.

As such, the EFVV would like to be quoted with the inclusion of the scientific facts.  The current portrayal of vaccine-critical individuals as “emotional, irrational and irresponsible” is an insult to the therapists, family members, carers and activists who have witnessed the harm caused by vaccination programs to this generation.  The increase in chronic neurological and immunological diseases recorded today is in fact proportional with the increasing number of vaccines delivered. This is the reality we face.

It is not only isolated scientists, activists or parents of vaccine-damaged children who question the safety of today’s vaccines.  After scientific research revealed a causal link between vaccines and many autoimmune diseases (AID) and cancer in Italian soldiers, an Italian parliamentary inquiry commission, Commissione parlamentare uranio impoverito-Inchiesta SIGNUM [4], issued the following imperative guidelines for vaccinating members of the military:

  1.   Before vaccination, all military personnel must undergo hypersensitivity and immune system assessment       tests to establish whether the vaccine might cause harm.
  2.   Single- rather than multiple-dose vaccines are recommended.
  3.   No more than five single vaccines may be given at any one time, due to the increased risk of causing AID        and cancer.
  4.   Every vaccinated individual must be monitored for ten years post-vaccination to determine what side         effects might manifest later.
  5.  Persons allergic to military vaccines will not be allowed to join the military.

We must also draw your urgent attention to the results of an independent vaccine ingredient analysis carried out recently in Italy by the Corvelva group, using independent laboratories [5], in correlation with the mechanisms of potential harm described here below.  The analyses revealed numerous impurities ranging from human and mice DNA to viruses, chemicals, etc., found in large quantities in the vials tested. Five out of seven vaccines do not conform to the guidelines for the quantity of biological material, DNA or foreign RNA of human or animal origin, or for the presence of genetic mutations of the antigens. It is therefore of utmost importance not only to lay the responsibility for vaccine safety and coherence with the ingredients labelled, in the hands of the Industry, but to insist that independent monitoring be introduced by the states recommending or mandating these vaccine programs.  Current regulatory systems are officially sponsored by the manufacturers or, as in the case of the CDC in the USA, the regulators even possess financial interests themselves by holding vaccine patents. The Cochrane Collaboration has frequently criticised this conflict of interest and lack of independence in the past.

In addition, today’s vaccine trials do not require a true placebo any more [6], making them invalid to judge safety from the moment the vaccines are launched on the market and administered to the public.  As a general rule, only young healthy males are recruited for these studies; the population studied is therefore not representative of the vaccine’s target market. A return to scientific industry standards should be a priority so that regulatory panels may make an informed statement about the actual safety of today’s vaccines.

The EFVV therefore sees it as necessary and overdue to reassess current vaccine programs and initiate an open and honest scientific discussion on this topic.  The Italian SIGNUM inquiry criteria should be applied not only to Italian military personnel, but to the general public wherever vaccine programs are imposed, in many cases by mandate.

It is not our aim to discuss the actual effectiveness of individual vaccines here (even if this is also a matter of grave concern) but to highlight proven potential pathways of harm through vaccines, most of which are in fact disregarded causes of the many current health problems in our children.  Please take the time to consider these points and create a platform for a balanced exchange and debate to secure the health of our children.

Mechanisms for potential neurological and immunological damage due to vaccines:

1.      Predisposing genetics and single nucleotide polymorphisms
MTHFR, apo E 4, COMT, VDR Taq, GST, etc.

2.      Environmental toxin background load 
i.e. metals, chemicals, etc.

3.      Vaccine damage via allergic reaction to the ingredients
i.e. gelatin, neomycin, etc.

4.      Vaccine damage via autoimmunity
i.e. ASIA

5.      Vaccine damage via Inflammation and cytokine release
i.e. aluminium and polysorbate 80 as strong immune stimulators

6.      Vaccine damage via toxic ingredients
i.e. aluminium, squalene, thimerosal, etc.

7.     Vaccine damage via adjuvants
i.e. aluminium as a strong immune stimulator

8.     Vaccine damage via contaminants 
i.e. viral and bacterial compounds found in around 60% of all vaccines

9.     Vaccine damage via cross peptide reactivity

10.    Vaccine damage via modification to the microbiome
i.e. mast cell stimulation from aluminium

11.    Synergistic effects with other neurotoxic agents
i.e. mercury, fluoride


Potential pathways for vaccine damage:

Predisposing genetics and associated single-nucleotide polymorphisms.

A variety of genetic markers have been associated with a decreased capacity of the body to detoxify.  The MTHFR polymorphism for example leads to a decrease in glutathione synthesis, one of the major elimination pathways of the body.  The majority of children in the autistic spectrum belong to this classification. APO E 4 has been associated with a range of neurological diseases and as such has been recognised as a major risk factor for Alzheimer’s disease.  Science will tell if these genetic markers will be a contraindication for drugs with neurotoxic ingredients, such as vaccines and the neurotoxic aluminium in them. Many children with vaccine side effects present with these markers and scientists are discussing whether children with the individual risk factors should not be vaccinated.

Environmental toxin load.

In toxicology, most substances are studied individually for their harmful effects.  We now know however that in order to judge the toxic effect we must also take their synergistic effect with other toxins into account.  Considering the increase in chemicals, heavy metals

etc. in our environment, we must look carefully at the cumulative damage potentially caused by individual substances working synergistically.  Aluminium on its own is neurotoxic. If we combine it with even small doses of mercury, the effect is much greater. If we take a dose of aluminium capable of killing one in one hundred rats and combine it with the dose of mercury capable of killing one in a hundred, the result is the death of all hundred rats observed.

Vaccine damage via allergic reaction to the ingredients.

Various vaccine ingredients have been shown to cause severe allergic reactions.  The MMR vaccine for example has been shown to trigger egg allergies since the viruses are cultivated on chicken eggs (Herman, 1983).  Other vaccine ingredients like the antibiotic neomycin (Kwittken, 1993), gelatin (Sakaguchi, 1995), yeast (Brightman, 1989), formaldehyde (Fabry, 1968), thimerosal (Cox, 1988), squalene (Asa, 2000), aluminium (Cosnes, 1990), hydrocarbon oils (Kuroda, 2004), etc. have demonstrated allergenic properties.  Even active vaccine components like the tetanus toxoid (Jacobs, 1982) have demonstrated this.

The effect on the foetal immune and nervous systems for example has not been studied and should be a subject of future studies to ensure safety for the unborn child in the case of vaccines given in pregnancy.  What is more, the results of the recent independent vaccine ingredient analysis organised by the Corvelva group in Italy, reveal that vaccines contain unknown ingredients with potential allergenic properties but these are not listed on the insert or in any document.  Under such circumstances, how can the allergenic potential or effects of such products be established?

Vaccine damage via autoimmunity.

An entire book by respected international authors on the connection between vaccines and autoimmunity was published by Prof. Shoenfeld (Vaccines and Autoimmunity, 2015).  In neurological problems of the central nervous system (CNS), autoantibodies against various brain structures, such as serotonin receptors, myelin basic protein, neuron axon filament protein, nerve growth factor and cerebellar neurofilaments, etc. (Fawal, 1996; Singh, VK, 1993/1997/2004; Singer, HS, 2006) have been observed.

Immunologists have now concluded that autoimmune disorders are not the result of excessive activation of a normal immune system but rather activation of a dysfunctional immune system.  There is also compelling evidence to indicate that certain vaccinations are associated with these autoimmune-related conditions (Shoenfeld, Y, 2000).

Ironically, substances that suppress a portion of the immune system, usually cellular type immunity, increase the likelihood of autoimmunity.  Immunologists speak about a Th1 to Th2 shift and vice versa. This can occur with exposure to mercury as well as in response to vaccination. A large number of autoimmune diseases are associated with a Th2 shift.

Vaccine damage via cytokines and excitotoxins.

Both animal and human studies show that systemic infections and also immune activation by vaccines, rapidly activate the brain’s microglial system; in fact, vaccines can do so for prolonged periods.  Practitioners report raised cytokines up to eleven years after an immunisation in vaccine-damaged individuals. Once the primed microglia are reactivated by a subsequent vaccination or infection, the microglia activate fully and secrete their destructive compounds as previously discussed.

The immune system can clear a natural infection quickly and then shut down the immune activation, thus allowing repair of what damage may have been caused.  This shutting down of the microglia is very important. There is evidence that with repeated and excessive vaccine-triggered immune stimulation, the microglia do not shut down.

Any inflammation via infection or vaccine will result in a release of cytokines.  Systemic inflammation has been shown to increase the risk of adverse neurological outcomes in extremely low gestation newborns (Kuban, 2015).  In low concentrations, cytokines act to protect developing brain cells and promote brain development (neurotrophic function), but in high concentrations they can be very destructive, especially in combination.

Of particular importance are the inflammatory cytokines interleukin 1 and 1β (IL-1 and IL-1β), IL-6, and tumour necrosis factor-alpha (TNF-α).  It is known, for example, that women who are infected with the flu during pregnancy are significantly more likely to give birth to an autistic child or a child with schizophrenia, depending on when the infection occurred.  At first, they assumed this was due to the virus being passed to the foetus, but subsequent studies found that it was not the virus, but the mother’s immune reaction that caused the problem—that is, it was the immune cytokines (IL-1, IL-2, Il-8, IL-6 and TNF-α) that were causing the injury to the baby’s developing brain.

Another cytokine is type I interferon.  Based on a series of experiments in mice and rats in the 1970s, Ion Gresser and colleagues drew attention to the possibility that inappropriate exposure to type I interferon (IFN) — for example, too much, for too long or at the wrong time — might be detrimental in mammals.  With remarkable prescience, they postulated that the embryo-toxic effects of congenital viral infection might directly relate to the host IFN response (induced by the infectious agent) rather than to the virus per se (Crow, 2015). In mammalian cells, immune responses to viral infection often involve host-encoded nucleic acid-binding, pattern-recognition receptors (PRRs), including endosomal Toll-like receptors (TLRs, namely TLR3, TLR7, TLR8 and TLR9), RNA sensors (including the retinoic acid-inducible gene I (RIG-I-like receptors (RLRs) IFIH1 and RIG-I) and DNA sensors (particularly cyclic GMP–AMP synthase (cGAS) and γ-IFN-inducible protein 16 (IFI16)).

Virus-encoded nucleic acids are recognised as non-self pathogen-associated molecular patterns (PAMPs) and the binding of viral PAMPs to PRRs triggers signalling cascades that act through the adaptor molecules TRIF (in the case of TLR3), MYD88 (in the case of TLR7 and TLR9), mitochondrial antiviral-signalling protein MAVS (in the case of the RLRs) and stimulator of IFN genes protein STING (in the case of cGAS and IFI16).

These pathways induce the expression of virus-responsive genes and pro-inflammatory cytokines (including the type I IFNs), which restrict virus replication and modulate innate and adaptive immunity (Crow, 2015).  Although the rapid induction and amplification of the type I interferon system is highly adaptive in terms of virus eradication, aberrant stimulation or unregulated control of the system could lead to inappropriate and/or excessive interferon output (Crow, 2013).

Interferons have been shown to be neurotoxic (Kessing, 2015) through activation of the type I receptor and the GIuN2A subunit of the NMDA receptor.

Type I interferons have even been suggested to be a future adjuvant in vaccines, which we hope, from our current knowledge, will not be implemented (Bracci, 2008).  It is of note that nucleic acids can also trigger inflammasome activation, which has been related to at least one human disease phenotype (Kaneko, 2011; Tarallo, 2012).

Following treatment with IFN (for example, for hepatitis C virus infection or as cancer therapy), numerous reports describe the occurrence of features such as digital vasculitis, SLE and glaucoma (Bessis, 2002; Ronnblom, 1990; Kwon, 2001).  IFN production could also be a mechanism of a vaccine potentially harming the brain. In the case of microcephaly in Brazilian children it could therefore be that a generally harmless Zika virus could cause cytokine production which can be harmful to the developing brain; it is also plausible that this occurred due to vaccination or as a third scenario, the combination of the two or even more factors as a cumulative overstimulation of the immune system.

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