A PubMed search on aluminum and “toxicity” turns up 4,258 entries. Its neurotoxicity is well documented. It affects memory, cognition, psychomotor control; it damages the blood brain barrier, activates brain inflammation, depresses mitochondrial function and plenty of research suggests it is a key player in the formation of the amyloid “plaques” and tangles in the brains of Alzheimer’s patients. It’s been implicated in Amyotrophic Lateral Sclerosis and autism and demonstrated to induce allergy.
When kidney dialysis patients were accidentally infused with aluminum, the “dialysis-induced encephalopathy” (DAE) they developed neurological symptoms: speech abnormalities, tremors, memory loss, impaired concentration and behavioural changes. Many of the patients eventually went into comas and died. The lucky ones survived: when the source of toxicity, aluminum, was removed from their dialysis they recovered rapidly.
With these new observations, researchers began investigating the adjuvant effects of aluminum and in the past decade there has been a flurry of research. Far from being a sandbag that holds the antigen for a while and then gets excreted, it turns out that aluminum salts trigger a storm of defence action. Within hours of injection of the same aluminum oxyhydroxide in vaccines into mice, for example, armies of specialized immune cells are on the move, calling in grid coordinates for more specialist assault forces. Within a day, a whole host of immune system commandos are in play — neutrophils, eosinophils, inflammatory monocytes, myeloid and dendritic cells, activating lymphocytes and secreting proteins called cytokines. The cytokines themselves cause collateral damage but they send out signals, directing cell-to-cell communication and recruiting other cells into action. If the next phase of the attack is launched: fibroblast growth factor, interferons, interleukins, platelet derived growth factor, transforming growth factor and tumour necrosis factor might all be engaged. There’s evidence that poorly understood and pesky inflammasomes, (currently a topic of cutting- edge cancer causation research) such as the Nod-like receptor 3( NLRP) are activated too, but it’s all still too early to say exactly what they’re doing.
New research emerging from University of British Columbia has found that aluminum adjuvant injected into mice can alter the expression of genes associated with autoimmunity. And in their recent study published in the Proceedings of the National Academy of Sciences, immunologists at the University of Colorado found that even host DNA is recruited into the aluminum assault, that it rapidly coats injected alum, triggering effects that scientists have barely scratched the surface of understanding.
THE SIGNIFICANCE OF MACROPHAGIC MYOFASCIITIS
This mobility or “translocation” of aluminum in the body is perhaps the most disturbing of the mounting evidence in current aluminum research. In 1998, French researcher Romain Gherardi and his colleagues observed an emerging condition of unknown origin which presented in patients post-vaccination with Chronic Fatigue like symptoms including swollen lymph nodes, joint and muscle pain and exhaustion. Tissue biopsies of the patients’ deltoid revealed lesions up to 1 cm in diameter and unique from similar lesions of other diseases. They went to the lab for analysis and to Gherardi’s astonishment, they mainly consisted of macrophages – large white blood cells in the immune system whose job is to swallow up foreign invaders in the body. Enclosed in the cellular fluid of these phagocytes were agglomerates of nanocrystals of aluminum.
Gherardi and his colleagues began injecting mice with aluminum to see what happened. Their research published in 2013 revealed that the metal particles were engulfed by macrophages and formed MMF-like granulomas that dispersed — to distant lymph nodes, spleen, liver and eventually the brain.
“This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite of slow brain translocation and delayed neurotoxicity,” writes Gherardi in his February 2015 review of the relevant research in Frontiers in Neurology.
A more frightening animal study of aluminum is that of Spanish veterinary researcher Lluis Lujan’s study of ovine ASIA. After huge numbers of sheep in Spain died in 2008 in the wake of compulsory multiple vaccine campaigns against bluetongue in Spain in 2008, Lujan set out to find out what killed them – and he began by inoculating them with aluminum.
His 2013 study found that only 0.5% of sheep inoculated with aluminum vaccines showed immediate reactions of lethargy, transient blindness, stupor, prostration and seizures – “characterized by a severe meningoencephalitis, similar to post-vaccine reactions seen in humans.” Most of them recovered, temporarily, but postmortem exams of the ones who didn’t reveal acute brain inflammation.
The delayed onset “chronic” phase of the disease affected far more of the sheep — 50-70% of flocks and sometimes virtually 100% of animals within a given flock, usually including all of those who had previously recovered. The reaction was frequently triggered by exposure to cold and began with restlessness and compulsive wool-biting, then progressed to acute redness of the skin, generalized weakness, extreme weight loss and muscle tremors, and finally, entered the terminal phase where the animals went down on their front quarters, became comatose and died. Post-mortem examinations revealed “severe neuron necrosis” and aluminum in the nerve tissue.
The immune system’s reaction to aluminum “represents a major health challenge,” Gerhardi declares in his recent review, and he adds that “attempts to seriously examine safety concerns raised by the bio-persistent character and brain accumulation of alum particles have not been made… A lot must be done to understand how, in certain individuals, alum-containing vaccines may become insidiously unsafe.”
Back to the problem of which “certain individuals” should avoid vaccination to avoid autoimmune disease.
PEOPLE PRONE TO DEVELOP AUTOIMMUNITY
Soriano and Shoenfeld’s identify a final category: anyone at risk of developing autoimmune disease. Since a number of them have been shown to have genetic factors that would include anyone with a family history of autoimmune disease. It also includes anyone who has tested positive for autoantibodies which can indicate disease years before symptoms show up. Vaccinations, the doctors say, “may trigger or worsen the disease.”
Smokers too, have an exceptionally high risk of developing an autoimmune disease, says the report. The American Cancer Society estimates that about 18% of Americans smoke. That means about 42 million Americans have an elevated risk of developing an autoimmune disease and they’re stacking the odds with every vaccine.
And finally, factors that Shoenfeld and Soriano associate with high risk of developing autoimmunity are high estrogen and low vitamin D — which means anyone taking birth control or hormone replacement therapy and, according to one 2009 study of vitamin D status, about three quarters of American teens and adults should be wary of vaccines.